For an oocyte being ready for fertilization and development into an embryo, the proper set of genes needs to be turned on. Namekawa suspected this pre-programming from the oocyte genome happens in quite a few stages — the main just one starting up around the time a feminine is born. He believed that chromatin remodeling proteins did Considerably of this get the job done, by shifting spools all over.
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“The organization of chromatin influences which genes may be expressed,” claims Namekawa. That’s because the specific areas of your spools, and also the spacing involving them, determines which stretches of DNA could be accessed by molecules referred to as transcription variables, which latch onto genes and turn them on.
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